DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.

Chantal Stoepker,Atiq Faramarz,Martin A Rooimans,Saskia E van Mil,Jesper A Balk,Eunike Velleuer,Najim Ameziane,Hein Te Riele,Johan P de Winter

DNA Repair（2015）

引用 26|浏览27

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摘要

•FANCM- and DDX11-deficient lymphoblasts are PARP inhibitor sensitive.•Variable PARP inhibitor sensitivity in different BRCA2-deficient lymphoblasts.•RAD51 focus formation is not a general biomarker for PARP inhibitor response.

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关键词

PARP inhibitor,Fanconi anemia,Warsaw breakage syndrome,Sister chromatid cohesion,FANCM,DDX11

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