Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice.

Objectives: To assess the association between histologic findings in the minor salivary gland biopsy (MSGB) and anti La (La/SS-B)y antiRo antibodies (Ro/SS-A), antinuclear antibodies (ANA) and Rheumatoid Factor (RF),and compare the value of the latter as diagnostic tests with MSGB, considered as the gold standard. Material and method: Patients with suspected Primary Sjogren Syndrome (PSS) referred for MSGB were included. Antibody measurements were performed. Grade III and IV biopsy results were considered positive. Results: Two hundred and eighteen (218) patients were included, 95% females, with a median age of 54 years and 12 months median duration of sicca symptoms. 36 of the biopsies were positive. 33% of patients had positive anti Ro/SS-A anti La/SS-B antibodies, 62% had positive ANA, and 31% positive RF. A statistically significant association was found between MSGB and anti Ro/SS-A anti La/SS-B, ANA and RF. ANA were the most sensitive antibodies (84%. 95% CI:75-92), and the most specific were: Anti Ro/SS-A and/or anti La/SS-B (78%. 95% CI: 71-85) and RF (78%. 95% CI: 69-87). Conclusion: On PSS clinical suspicion, anti Ro/SS-A y anti La/SS-B antibodies have a great value to achieve the diagnosis, with MSGB useful for diagnosis of seronegative patients. The results also suggest the importance of ANA and RF for PSS classification. (C) 2015 Elsevier Espana, S.L.U. All rights reserved.