黄芩汤在大鼠发热状态下药效学及药代动力学特征研究
Yao xue xue bao = Acta pharmaceutica Sinica(2014)
Abstract
研究发热状态下黄芩汤的药效学和药代动力学特征.大鼠酵母菌造模后,给予黄芩汤20 g·kg-1,不同时间点取血,同时测定血药浓度、炎性介质和直肠温度的变化.结果黄芩汤能降低酵母菌致发热大鼠的体温,能降低血中前列腺素PGE2、白细胞介素IL-1β和肿瘤坏死因子TNF-α的含量.发热状态下,黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、千层纸素A、甘草酸和甘草次酸等成分的吸收速率减缓,体内的清除率降低,体内滞留时间延长,Cmax和AUC增大,发热能影响黄芩汤体内的药代动力学行为;黄芩苷和汉黄芩苷,黄芩素和汉黄芩素、千层纸素A的体内过程类似,同属于中速吸收、中速消除类成分;黄芩素、汉黄芩素的血药浓度和黄芩汤解热效应之间具有较强的正相关关系.
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Key words
Huangqin Tang,flavonoids,LC-MS,pharmacokinetics,pharmacodynamics
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