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Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells through the PI3K/Akt/mTOR signaling pathway

Rui Wen,Shenqiang Hu,Qihai Xiao,Chunchun Han,Chao Gan,Hua Gou,Hehe Liu,Liang Li,Hengyong Xu,Hua He,Jiwen Wang

The Journal of Steroid Biochemistry and Molecular Biology（2015）

Cited 40|Views56
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Abstract
•Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells.•The mechanism involves the activation of the PI3K/Akt/mTOR signaling pathway.•Leptin exerts its effects by regulating expression of its receptor.
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Key words
Akt,AMPK,BrdU,CCK-8,IRS,JAK/STAT,Lepr,MAPK,mTOR,PDK1,PI3K,PIP2,PIP3,p-S6K,qRT-PCR,S6K,TUNEL
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