Chemical constituents on the aerial parts of Artemisia selengensis and their IL-6 inhibitory activity

Ten compounds, 1′,3′-propanediol,2′-amino-1′-(1,3-benzodioxol-5-yl) ( 1 ), artanomaloide ( 2 ), canin ( 3 ), eupatilin ( 4 ), quercetin-3- O - β - d -glucoside-7- O -α- l -rhamnoside ( 5 ), 1,3-di- O -caffeoylquinic acid ( 6 ), isoquercitrin ( 7 ), pinoresinol-4- O - β - d -glucoside ( 8 ), scopolin ( 9 ), and isofraxidin-7- O - β - d -glucopyranoside ( 10 ) were isolated from the aerial parts of A. selengensis . The structures of compounds ( 1 – 10 ) were identified based on 1D and 2D NMR, including 1 H– 1 H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among them, compound 1 was isolated from this plant for the first time as a naturally occurring compound. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cells was also examined.