EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

Brent Neumann,Sean Coakley,Rosina Giordano-Santini,Casey Linton,Eui Seung Lee,Akihisa Nakagawa,Ding Xue,Massimo A. Hilliard

NATURE（2015）

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摘要

Unlike the limited post-injury neuronal regeneration in humans, severed axons in C. elegans can regenerate through a cellular fusion mechanism; this study identifies the molecular basis for this process which includes phosphatidylserine recognition and a role for specific molecules that also act in apoptosis.

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关键词

Regeneration and repair in the nervous system, Apoptosis

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