Plaque array method and proteomics-based identification of biomarkers from Alzheimer's disease serum.

•Development of a novel plaque array method for detection and characterization of serum derived insoluble plaque particles•Plaque array is a flow cytometer and proteomics based method for identification of biomarker using Alzheimer's disease serum•Flow cytometer based identification and measurement of serum induced abeta-42, cholesterol, tau and α-synuclein plaque particles for diagnosis of Alzheimer's disease•Proteomic analysis of plaque particles show 195 proteins bound to different plaque particles•Abeta-42 particles contain more specific serum proteins compared to cholesterol, tau and α-synuclein particles