Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis.

Angèle Gayet-Ageron,Patrice Sednaoui,Stephan Lautenschlager,Tristan Ferry,Laurence Toutous-Trellu,Matthias Cavassini,Fatima Yassir,Begoña Martinez de Tejada,Stéphane Emonet,Christophe Combescure,Jacques Schrenzel,Thomas Perneger

EMERGING INFECTIOUS DISEASES（2015）

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摘要

Treponema pallidum PCR (Tp-PCR) has been noted as a valid method for diagnosing syphilis. We compared Tp-PCR to a combination of darkfield microscopy (DFM), the reference method, and serologic testing in a cohort of 273 patients from France and Switzerland and found the diagnostic accuracy of Tp-PCR was higher than that for DFM.

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关键词

Treponema pallidum,Tp47 protein,sensitivity,specificity,syphilis,PCR

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