Effects of Xuezhikang in patients with dyslipidemia: a multicenter, randomized, placebo-controlled study.

►Xuezhikang (XZK) is an extract of red yeast rice with lipid-lowering effects.►Daily XZK 1200 to 2400 mg for 12 weeks decreased non−HDL-C by approximately 24% and LDL-C by approximately 27%.►XZK treatment at either dose enabled approximately 50% of patients to achieve a ≥30% decrease in LDL-C.►Xuezhikang was well tolerated. No subject developed myopathy.►Efficacy did not differ in American vs Chinese subjects.