Structural features of endocrine active chemicals – A comparison of in vivo and in vitro data

Reproductive Toxicology(2015)

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摘要
•89 chemical structural features assessed for endocrine properties in vivo and in vitro.•High correlation for endocrine effects in vivo with estrogenic properties in vitro.•Lack of published negative study data is obvious.
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关键词
Category approach,Estrogen receptor,Reproductive toxicity,Predictive screening,Toxicological databases,Structural features
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