Generation of a chickenized catalytic anti-nucleic acid antibody by complementarity-determining region grafting.

•Reshaping of a mouse catalyic anti-DNA antibody to a chicken antibody was approached.•Chickenized antibody retained structure similar to original mouse antibody.•Chickenized antibody retained biochemical properties similar to mouse antibody.•CDR-grafting was applicable to reshaping of a mouse antibody to a chicken antibody.