Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation.

•We tested if acute neuroinflammation impairs retrieval of different memory tasks.•Systemic LPS administration was used to induce acute neuroinflammation in brain.•Systemic LPS did not affect novel object recognition or spatial memory tasks.•Systemic LPS impaired context–object discrimination memory.•Acute neuroinflammation affects specific forms of hippocampus-dependent memories.