Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity.

Jarrett T Whelan,Lei Wang,Jianming Chen,Meagan E Metts,Taj A Nasser,Liam J McGoldrick,Lance C Bridges

Biochemical and Biophysical Research Communications（2014）

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摘要

•Transcription and translation are required for retinoid-induced lymphocyte adhesion.•RAR activation is sufficient to induced lymphocyte cell adhesion.•Vitamin D derivatives inhibit RAR-prompted lymphocyte adhesion.•Adhesion occurs through a novel binding site within ADAM disintegrin domains.•RARα is a key nuclear receptor for retinoid-dependent lymphocyte cell adhesion.

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关键词

1,25-(OH)2D3,ADAM,atRA,CHX,Dex,RA,MPSS,MAdCAM-1,RAR,RXR

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