Aurora-A kinase: potential tumor marker of osteosarcoma.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS(2014)
Abstract
Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.
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Key words
Aurora-A kinase,biomarker,oncogene,osteosarcoma,prognosis
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