Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth.
Molecular and Cellular Endocrinology（2015）
Abstract
•IGFBP3 and PPARγ interact to inhibit breast cancer cell growth.•Downregulation of IGFBP-3 reverses the inhibitory effect of PPARγ ligands.•IGFBP-3 mutants with deficient PPARγ binding block the inhibitory effect of PPARγ ligands.•IGFBP-3 expression by breast tumors may sensitize them to inhibition by PPARγ ligands
MoreTranslated text
Key words
IGF,IGFBP-3,RARα,VDR,PPARγ,RXRα,atRA,15d-PGJ2,TZD
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined