Diaphragm dysfunction caused by sphingomyelinase requires the p47phox subunit of NADPH oxidase
Respiratory Physiology & Neurobiology(2015)
Abstract
•Sphingomyelinase increases phosphorylation of p47phox in diaphragm muscle.•p47phox knockout prevents sphingomyelinase-induced increases in diaphragm oxidants.•p47phox knockout prevents diaphragm weakness elicited by sphingomyelinase.
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Key words
Sphingolipids,Force,and Nox
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