PXD101 significantly improves nuclear reprogramming and the in vitro developmental competence of porcine SCNT embryos.

Jun-Xue Jin,Jin-Dan Kang,Suo Li,Long Jin,Hai-Ying Zhu,Qing Guo,Qing-Shan Gao,Chang-Guo Yan,Xi-Jun Yin

Biochemical and Biophysical Research Communications（2015）

引用 15|浏览16

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摘要

•First explored that the effects of PXD101 on the development of SCNT embryos in vitro.•0.5μM PXD101 treated for 24h improved the development of porcine SCNT embryos.•Level of AcH3K9 was significantly higher than control group at early stages.

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关键词

PXD101,Histone deacetylase inhibitor (HDACi),Somatic cell nuclear transfer (SCNT),In vitro development,Blastocyst

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