Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination.

Geert Leroux-Roels,Pascale Van Belle,Pierre Vandepapeliere,Yves Horsmans,Michel Janssens,Isabelle Carletti,Nathalie Garçon,Martine Wettendorff,Marcelle Van Mechelen

Vaccine（2015）

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摘要

•HBsAg in combination with MPL/QS-21 Adjuvant Systems was highly immunogenic.•CD4+ T-cell, memory B-cell and antibody responses persisted for at least 4 years.•Vaccine adjuvant systems offer potential for challenging diseases or populations.

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关键词

Adjuvants,Cellular immunity,MPL,QS-21,Adjuvant system,Vaccine

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