Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones
Organic & Biomolecular Chemistry（2015）
Abstract
Amides and ketones were intramolecularly coupled in the presence of KOt-Bu/DMF. The reaction provided good yields of a variety of isoquinolinones. A reaction mechanism of radical addition and subsequent E2-elimination is proposed.
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Key words
Drug Synthesis
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