A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin
NATURE CHEMICAL BIOLOGY(2014)
摘要
Peptide natural product backbones are typically made ribosomally or by NRPS machinery. Exploration of pheganomycin biosynthesis defines a third hybrid model in which a grasp ligase joins an NRPS product with a ribosomally produced peptide.
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nature chemical biology, science
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