A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin

Motoyoshi Noike,Takashi Matsui, Koichi Ooya,Ikuo Sasaki,Shouta Ohtaki,Yoshimitsu Hamano,Chitose Maruyama,Jun Ishikawa,Yasuharu Satoh,Hajime Ito,Hiroyuki Morita,Tohru Dairi

NATURE CHEMICAL BIOLOGY（2014）

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摘要

Peptide natural product backbones are typically made ribosomally or by NRPS machinery. Exploration of pheganomycin biosynthesis defines a third hybrid model in which a grasp ligase joins an NRPS product with a ribosomally produced peptide.

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nature chemical biology, science

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