Structure and specificity of FEN-1 from Methanopyrus kandleri.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS(2015)
摘要
DNA repair is fundamental to genome stability and is found in all three domains of life. However many archaeal species, such as Methanopyrus kandleri, contain only a subset of the eukaryotic nucleotide excision repair (NER) homologs, and those present often contain significant differences compared to their eukaryotic homologs. To clarify the role of the NER XPG-like protein Mk0566 from M. kandleri, its biochemical activity and three-dimensional structure were investigated. Both were found to be more similar to human FEN-1 than human XPG, suggesting a biological role in replication and long-patch base excision repair rather than in NER. Proteins 2015; 83:188-194. (c) 2014 Wiley Periodicals, Inc.
更多查看译文
关键词
protein-DNA complex,DNA nuclease,nucleotide excision repair
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要