[Impact of Toxoplasma Gondii Infection on Pregnancy Outcomes in Early Pregnant Women].

OBJECTIVE:To explore the impact of Toxoplasma gondii infection on pregnancy outcomes in early pregnancy women. METHODS:Toxoplasma gondii IgM and IgG antibodies in the peripheral blood of 2 993 early pregnant women were detected by using enzyme-linked immunosorbent assay (ELISA). According to the test results, the infected ones were divided into an acute infection group, a previous infection group, and an active infection group, and 200 pregnant women without Toxoplasma infection were randomly chosen as a control group, and the pregnancy outcomes of the four groups were followed up and the results were compared. RESULTS:There were 286 women infected with Toxoplasma gondii, with the infection rate of 9.56% (286/2 993), in which 43 cases were diagnosed as acute infection, 156 were previous cases, and the other 87 were active infection ones. The incidences of adverse pregnancy outcomes in the above 3 groups and the control group were 13.95% (6/43), 1.92% (3/156), 5.75% (5/87) and 1.50% (3/200), respectively. The incidences of adverse pregnancy outcomes in the acute infection group and active infection group were both higher than that in the control group, the differences were statistically significant (both P < 0.05), while there was no significant difference between the previous infection group and control group (P > 0.05). CONCLUSION:Acute and active Toxoplasma gondii infections are closely associated with the occurrence of adverse pregnancy outcomes in early pregnant women; therefore, Toxoplasma gondii IgM antibody should be included in the routine inspection items of the pre-pregnancy physical examination for child-bearing age women.