The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance.

Allisson Jhonatan Gomes Castro,Marisa Jádna Silva Frederico,Luisa Helena Cazarolli,Camila Pires Mendes,Lizandra Czermainski Bretanha,Éder Carlos Schmidt,Zenilda Laurita Bouzon,Veronica Aiceles de Medeiros Pinto,Cristiane da Fonte Ramos,Moacir Geraldo Pizzolatti,Fátima Regina Mena Barreto Silva

Biochimica et Biophysica Acta (BBA) - General Subjects（2015）

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摘要

•Ursolic acid is an insulin secretagogue.•Ursolic acid induces GLUT4 synthesis and translocation.•Ursolic acid is a potential anti-diabetic nutraceutical agent.

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关键词

Calcium,Secretagogue,GLUT4,Hyperglycemia,Insulin,Triterpene

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