p100, a precursor of NF-κB2, inhibits c-Rel and reduces the expression of IL-23 in dendritic cells.
Biochemical and Biophysical Research Communications（2014）
Abstract
•The deficiency of p100 enhances c-Rel-, not RelA-, dependent cytokine expression.•p100 associates with c-Rel in the steady state but dissociates after LPS stimulation.•The deficiency of p100 enhances the nuclear translocation of c-Rel.•p100 negatively regulates the c-Rel function.
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Key words
BMDC,HPRT,IFN,LPS,NF-κB,PLA,TLR,TNF
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