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Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China.

Yuzi Luo,Na Li,Xin Cong,Chun-Hua Wang,Min Du,Lin Li,Bibo Zhao,Jin Yuan,Dan-Dan Liu,Su Li,Yongfeng Li,Yuan Sun,Hua-Ji Qiu

Veterinary Microbiology（2014）

Cited 144|Views27
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Abstract
•The PRV variant TJ strain was isolated from a vaccinated pig farm in China.•Bartha-K61 strain could not provide complete protection from TJ strain challenge.•TJ strain exhibited higher pathogenicity in mice and pigs, compared with SC strain.•The TJ strain genome showed extensive, unique variations in most viral proteins.
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Key words
Pseudorabies virus,Variant,Pathogenicity,Complete genome sequence,Phylogenetic analysis
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