Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles.
International Journal of Pharmaceutics(2014)
摘要
The aim of this study is to characterize the in-vitro physicochemical and in-vivo pharmacokinetic properties of the scutellarin-loaded bovine serum albumin nanoparticles (STA-BSA-NPs). STA existed as amorphous form in the nanoparticles. Reconstituted STA-BSA-NPs had an average particle size of 283.4nm and a zeta potential of +17.95mV. The in-vitro sustained release profile was well fitted with Weibull distribution model. In comparison to STA solution, STA-BSA-NPs exhibited a significantly higher plasma concentration from 20min to 6h after intravenous administration to rats. In addition, significantly higher AUC0–inf (2.8-fold), prolonged elimination half-life (4.2-fold) and lower clearance (2.7-fold) were achieved.
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关键词
Scutellarin,Albumin nanoparticles,Sustained release,Elimination half-life,Bioavailability
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