Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation.

Malgorzata A Gil,Michael Caniga,Janice D Woodhouse,Joseph Eckman,Hyun-Hee Lee,Michael Salmon,John Naber,Valerie T Hamilton,Raquel S Sevilla,Kimberly Bettano,Joel Klappenbach,Lily Moy,Craig C Correll,Francois G Gervais,Phieng Siliphaivanh,Weisheng Zhang,Jie Zhang-Hoover,Robbie L McLeod,Milenko Cicmil

European Journal of Pharmacology（2014）

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摘要

Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical relationship between A. alternata and asthma, we sought to investigate the allergic activity of this antigen after direct application to the lungs of Brown Norway rats.

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关键词

A. alternata,OVA,Th2,CRTH2,MK-7246,ST2 (IL-1R1),ILC2,IL-4,IL-5,IL-25,IL-18,IL-6,IL-1 β,PAR-2,BN,BAL fluid,PBS,PGD2,MIP-1α,RANTES,MCP-1,AFA,TSLP

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