Activation of TGFβ1 signaling enhances early dopaminergic differentiation in unrestricted somatic stem cells.

Akram Mokhtarzadeh Khanghahi,Bahman Zeynali,Azimeh Akhlaghpoor,Azita Parvaneh Tafreshi,Kerstin Krieglstein

Neuroscience Letters（2014）

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摘要

•We investigated the role of TGFβ signaling in neural differentiation of USSCs.•Components of TGFβ signaling were present and functional in undifferentiated USSCs.•Activation of TGFβ signaling in USSCs enhances expression of neural markers.•TGFβ signaling is involved in early dopaminergic differentiation of USSCs.

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关键词

TGFβ signaling,USSC,Dopaminergic differentiation

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