AMP-activated protein kinase activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.

Guoqiang Lv,Huanhuan Zhu,Feng Zhou,Zhou Lin,Gang Lin, Chenwan Li

Biochemical and Biophysical Research Communications（2014）

Cited 29|Views6

No score

Abstract

•H Pylori activates AMPK in transformed and primary gastric epithelial cells (GECs).•AMPK inhibitor compound C increases apoptosis by H Pylori in GECs.•AMPK knockdown by targeted shRNAs promotes apoptosis in H pylori-infected GECs.•AMPK activators, or AMPKα1 over-expression, inhibits H Pylori-induced GEC apoptosis.•TAK1 potentially serves as upstream kinase to mediate AMPK activation by H pylori.

Translated text

Key words

AMPK,ACC,GECs,H pylori,ROS,shRNA,TGF-β,TAK1,TUNEL

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined