Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats.

J L Santerre,J A Rogow,E B Kolitz,R Pal,J D Landin,E D Gigante,D F Werner

Neuroscience（2014）

Cited 13|Views4

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Abstract

•AMPA receptor GluA2 subunits and atypical PKC isoforms are elevated during adolescence.•GluA2-containing receptors and atypical PKC regulation may contribute to ethanol cognitive sensitivity across age.•Demonstrates that a ZIP-sensitive kinase modulates GluA2 subunit phosphorylation in the presence of ethanol.

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Key words

ANOVA,aPKC,cPLA2,EDTA,LTP,NSF,PBS,PKC,SDS,SDS–PAGE,ser880,ZIP

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