Electroacupuncture At He-Mu Points Reduces P2x(4) Receptor Expression In Visceral Hypersensitivity
NEURAL REGENERATION RESEARCH(2013)
Abstract
Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X(4) receptor immunoreactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X(4) receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X(4) receptor immunoreactivity in the colon and spinal cord.
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Key words
neural regeneration, traditional Chinese medicine, combination of He-Mu points, electroacupuncture, irritable bowel syndrome, visceral hypersensitivity, P2X(4) receptor, acupuncture, grants-supported paper, neuroregeneration
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