Gremlin-1 inhibits macrophage migration inhibitory factor-dependent monocyte function and survival
International Journal of Cardiology(2014)
摘要
•Grem1 decreases MIF-dependent monocyte migration and adhesion in vitro.•Intravenous administration of Grem1 inhibits leukocyte adhesion in vivo.•Grem1 reduces MIF-induced differentiation of monocytes into macrophages.•Grem1 inhibits the anti-apoptotic impact of MIF on monocytes.
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关键词
Gremlin-1,MIF,Monocyte,Migration,Apoptosis
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