The lane to the brain: how African trypanosomes invade the CNS.

Stefan Mogk,Andreas Meiwes,Christian M Boßelmann,Hartwig Wolburg,Michael Duszenko

Trends in Parasitology（2014）

引用 35|浏览18

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摘要

•African trypanosomes settle in the pia mater and induce a chronic meningeal stage.•Long slender trypanosomes are formed during the meningeal stage.•African trypanosomes enter the choroid plexus and cross the blood–CSF barrier.•Bloodform trypanosomes do not survive in brain parenchyma after intrathecal application.

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关键词

sleeping sickness,Trypanosoma brucei,blood–brain barrier,blood–CSF barrier,CNS infection

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