[ED50 of dexmedetomidine nasal drip in induction of hypnosis in children during computed tomography].

OBJECTIVE:To explore the 50% effective dose (ED₅₀) of dexmedetomidine nasal drip in the induction of hypnosis in children during computed tomography (CT). METHODS:A total of 34 American Society of Anesthesiologists (ASA)I-IIautistic children scheduled for brain CT examination were studied. The induction was made by dexmedetomidine nasal drip and the ED₅₀ of dexmedetomidine determined by up-and down sequential experiment.When eyelash reflex became lost or Ramsay score was ≥ 4 in 1 hour after dosing, hypnosis was achieved. The study ended after 8 crossovers (successive "accept" and "refuse"). RESULTS:Among them, the ED₅₀ of dexmedetomidine was 1.76 µg/kg (95% confident interval:1.64-1.88 µg/kg). CONCLUSION:The ED₅₀ of dexmedetomidine nasal drip is 1.76 µg/kg in the induction of hypnosis in children.