Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice
Food and Chemical Toxicology（2014）
Abstract
•VPA induced depletion of cytosolic Nrf2 and suppression of nuclear translocation of Nrf2.•Increased levels of NF-κB and proinflammatory cytokines were observed in the liver of VPA-treated mice.•DG attenuates VPA induced hepatotoxicity by activation of Nrf2 and inhibition of NF-κB.
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Key words
Valproic acid,Hepatotoxicity,Diammonium glycyrrhizinate,Nrf2,NF-κB,Cytokines
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