The effects of rapamycin on regulatory T cells: Its potential time-dependent role in inducing transplant tolerance
Immunology Letters（2014）
Abstract
•We systematically analyzed data on the effects of RAPA on Treg cells.•RAPA appeared to maintain Treg cells better than CNI in transplant recipients.•The effect of RAPA on Treg cells might be time-dependent.•Treg cells in different proliferative stages have varying sensitivities to RAPA.•The possible mechanism was also discussed in our review.
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Key words
Rapamycin,Regulatory T cells,Transplantation,Tolerance induction,Time-dependent effects,Systematic review
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