Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells.
NANOSCALE(2015)
Abstract
Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin alpha(v)beta(3) receptors on glioblastoma cells with high internalization efficacy.
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Key words
fluorescent nanodiamonds,nanobiointerface,cancer
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