A Fasciola hepatica-derived fatty acid binding protein induces protection against schistosomiasis caused by Schistosoma bovis using the adjuvant adaptation (ADAD) vaccination system.

Belén Vicente,Julio López-Abán,José Rojas-Caraballo,Luis Pérez del Villar,George V Hillyer,Antonio R Martínez-Fernández,Antonio Muro

Experimental Parasitology（2014）

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摘要

•rFh15 protein induces a reduction in the parasite burden in S. bovis murine model.•Vaccine effectiveness against S. bovis depends on adjuvant formulation.•ADAD system using PAL as immunomodulator offer a new vaccination strategy.•rFh15 formulated on ADAD system induced high levels of IL-1 and IL-6 cytokines.

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关键词

Fatty acid-binding protein,Schistosoma bovis,Vaccine,Adjuvant

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