Long-term urodynamic evaluation of laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer.

The long-term urodynamics of laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer remain unclear in the clinical setting. The present prospective observational study was conducted between January 2010 and December 2012 to evaluate the 6-month and 12-month follow-up data of urodynamic changes of bladder cancer patients who were initially treated by laparoscopic radical cystectomy with orthotopic ileal neobladder. A total of 53 eligible patients were included, and all patients were followed up for at least 12 months, with a median time of 18 months. During the follow-up period, no patients reported difficulty urinating, and the daily frequency of urination and the urine output were gradually improved with time. Dynamic urodynamic examinations showed that the maximum flow rate (11.4 +/- 1.1 vs. 7.3 +/- 1.4 ml/sec; P<0.001), residual urine content (22.8 +/- 10.5 vs. 40.7 +/- 12.7 ml; P<0.001), maximum bladder capacity (373.8 +/- 62.2 vs. 229.7 +/- 56.3 ml; P<0.001) and maximum bladder pressure during filling (35.8 +/- 6.7 vs. 26.4 +/- 7.0 cm H2O; P<0.001) at 12 months were all improved significantly compared with that at 6 months after the initial surgical treatment. However, there were no significant differences in maximum bladder pressure during voiding (75.7 +/- 24.7 vs. 73.1 +/- 24.7 cm H2O; P=0.618) and bladder compliance (26.9 +/- 13 vs. 27.4 +/- 13.1 cm H2O; P=0.848) at 12 and 6 months after initial surgical treatment. In conclusion, the urodynamics of this orthotopic ileal neobladder gradually improve, and its long-term urine storage and voiding functions are acceptable.