Hydrogen sulphide triggers VEGF-induced intracellular Ca²⁺ signals in human endothelial cells but not in their immature progenitors.

•We studied the pro-angiogenic Ca2+ signals induced by H2S in mature and immature endothelial cells.•H2S induces InsP3-dependent Ca2+ release in Ea.hy926 cells, a surrogate of mature endothelial cells.•H2S does not elicit any detectable Ca2+ signal in endothelial progenitor cells (EPCs).•The blockade of H2S synthesis prevents the Ca2+ response to VEGF in Ea.hy926 cells, but not in EPCs.•The blockade of H2S abrogates VEGF-induced angiogenesis in Ea.hy926 cells, but not in EPCs.