Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: Possible role of this effect in the pathogenesis of indomethacin-induced renal damage

•Indomethacin administration induced tubular and glomerular damage in the kidney.•Levels of the active dimeric form of eNOS, but not iNOS, were reduced.•This was associated with induction of HO-1 and reduction in renal heme levels.•Renal nitrite levels were decreased, indicating lowered NO production.•Reduced NO levels may impair renal perfusion, leading to renal damage.