Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1α.

Neuroscience（2014）

Cited 22|Views2

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Abstract

•Hydrogen peroxide reduces viability of SK-N-MC cells through up-regulation of Bax.•Quercetin inhibits H2O2-induced up-regulation of Notch1, Foxo3a and HIF-1α.•Attenuation of HIF-1α expression enhances H2O2-induced apoptosis.•HIF-1α deficiency suppresses Foxo3a and NICD accumulation.

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AD,CAT,DAPT,DCFH-DA,DMSO,DTNB,EDTA,EGTA,EtBr/AO,FBS,GPX,GSH,H2O2,HIF,MDA,MTT,NICD,PHD,PBS,PCO,ROS,TBA,TCA

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