Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells.
Virus Research(2014)
Abstract
•The PRRSV Nsp3 or E protein was demonstrated to interact with IFITM1 or Tetherin.•The Nsp3 was shown to induce the proteasome-dependent degradation of IFITM1.•The E protein was proposed to partially remove Tetherin away from cell surface.•PRRSV might counteract cellular IFITM1 and Tetherin by its Nsp3 and E protein.
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Key words
Porcine reproductive and respiratory syndrome virus (PRRSV),Nonstructural protein 3 (Nsp3),Envelope protein (E),IFITM1,Tetherin,Interaction
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