FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.

M J García-Fuster,R Díez-Alarcia,M Ferrer-Alcón,R La Harpe,J J Meana,J A García-Sevilla

Neuroscience（2014）

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摘要

In the prefrontal cortex of subjects with major depression (drug-free) the pro-survival ratio p-FADD/FADD is increased, which could play a major role to counteract the activation of the mitochondrial apoptotic pathway.

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关键词

Bax,Bcl-2,ERK,FADD,GAPDH,MAPK,MD,MEK,mRNA,p,PARP-1,PEA-15,PFC/BA9,PMI,RNI,RT-qPCR,SEM,SZ

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