Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado–Joseph disease

X.P. Lin, L. Feng, C.G. Xie,D.B. Chen,Z. Pei,X.L. Liang, Q.Y. Xie, X.H. Li, S.Y. Pan

International Journal of Developmental Neuroscience（2014）

Cited 24|Views6

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Abstract

•The cell viability was found significantly decreased over time in the SCA3-Q84 cell line, whereas remained unchanged in the SCA3-Q28 cell line.•VPA significantly improved the SCA3-Q84 cell viability and suppressed expanded polyQ-induced cytotoxicity, but not the number of inclusions.•Expanded ataxin-3 suppressed the expression of acetylated histone H3 while VPA reversed the histone hypoacetylation.•VPA attenuates the expanded polyQ-induced down-regulation of CRE-dependent transcriptional activation.

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Key words

MJD,Valproic acid,HDAC inhibitor,CREB

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