Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia.
HYPERTENSION IN PREGNANCY(2014)
摘要
Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio >= 85 and normal angiogenic preeclampsia with sFlt1/PlGF585. The placental lesions of vascular insufficiency that were studied specifically included atherosis, infarcts, syncytial knots, acute and chronic abruption, hematoma, and fetal thrombosis. The data are shown as median (quartile 1 and quartile 3) or n (%) when appropriate. Results: The anti-angiogenic preeclampsia group (N=48) presented at an earlier gestational age (weeks) than the normal angiogenic group (N=28); {32 (28, 34) versus 35 (32, 36), p=0.002}, had higher systolic blood pressure (mmHg) {154 (147, 168) versus 147 (132, 158), p=0.02}, delivered early (weeks) {(32 (29, 34) versus 36 (34, 37), p<0.001} and had lower birth weight (grams) {(1550 (1055, 2060) versus 2655 (2285, 3343), p<0.001}. Several pathologic lesions were found significantly more often in the anti-angiogenic preeclampsia group; atherosis {27.7% versus 3.6%, p<0.05}, infarcts {58.3% versus 3.6%, p=0.002}, and syncytial knots {81.3% versus 39.3%, p<0.001}. Conclusion: Preeclamptic patients with imbalance in circulating angiogenic factors have disproportionally higher rates of placental vascular lesions historically associated with severe disease.
更多查看译文
关键词
Angiogenic factors,Placenta,Placental lesions
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要