Development of an online-SPE-LC-MS method for the investigation of the intestinal absorption of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and its bacterial metabolite PHIP-M1 in a Caco-2 Transwell system.

Ina Willenberg,Leonie von Elsner,Pablo Steinberg,Nils Helge Schebb

Food Chemistry（2015）

Cited 13|Views1

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Abstract

•Development of an online-SPE-LC-MS method for PHIP, N-OH-PHIP, 4-OH-PHIP and PHIP-M1.•Similar intestinal absorption of PHIP-M1 and PHIP in a Transwell system with a Caco-2 cell-monolayer.•Bacterial metabolites could contribute to the toxicity of heterocyclic aromatic amines.

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Key words

PHIP,PHIP-M1,Papp,HCA,CE,CV,FCS,SPE,TEER,PFP

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