The mitochondrial genome in aging and senescence.

Andrea Lauri,Giulio Pompilio,Maurizio C Capogrossi

Ageing Research Reviews（2014）

引用 59|浏览6

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摘要

•Mitochondria are central to aging.•mtDNA mutations can cause aging.•ROS are central in aging and senescence as mutating agent and signaling molecules.•ROS induce p53 and TERT switch from protective to detrimental activity.•miRNAs contribute to aging and senescence by targeting mitochondrial processes.

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关键词

Aging,Senescence,Mitochondria,mtDNA,ROS,Molecular mechanisms

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