A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus.
JOURNAL OF VIROLOGY(2014)
摘要
Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein. Following challenge of susceptible mice, we identified a significant reduction in virulence in the novel virus. We also identified an instability leading to reversion of the single mutation to a wild-type genotype.
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关键词
machupo virus,glycoprotein,transmembrane region
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