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HSPA5 is an essential host factor for Ebola virus infection.

St Patrick Reid,Amy C Shurtleff,Julie A Costantino,Sarah R Tritsch,Cary Retterer,Kevin B Spurgers,Sina Bavari

Antiviral Research（2014）

Cited 82|Views26
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Abstract
•Targeting HSPA5 chaperone activity inhibits EBOV.•EBOV transcript and protein production is impaired in the absence of HSPA5.•Targeting HSPA5 in vivo protects mice from lethal EBOV.
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Key words
Ebolavirus,HSPA5,Antiviral
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